Hyde's word choice here is probably an anachronism--hopefully not too much of one, but I'm not sure how quickly the word "lesbian" caught on to refer to, uh, lesbians.
The Lodgers' acute but largely nonjudgmental interest in Frankenstein's gender/sexuality is also probably a bit of an anachronism. Or it might not be, given how far "bohemian" counter-cultures could deviate from traditional Victorian sensibilities. I would hope that real Victorians of any social station would have a better sense of priorities in the face of Dr. Moreau, but I don't know that for sure either. Any Victorian with their survival instincts truly intact would probably opt not to live in London in the first place.